GRECCAR6: A multicentric randomized controlled trial on the impact of lengthening the interval between neoadjuvant radiochemotherapy and surgery on complete pathological response in rectal cancer (GRECCAR-6 trial): rationale and design

Trial Overview

AcronymGRECCAR6
NumberNCT01648894
Protocol Linkhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848646/
Public Trial Registry Linkhttps://clinicaltrials.gov/ct2/show/NCT01648894?term=greccar6&rank=1
Published Results Linkhttp://ascopubs.org/doi/abs/10.1200/JCO.2016.67.6049?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
StatusPublished
CategoryColorectal Cancer - Rectal Specific
Treatment CourseNeoadjuvant

Trial Description

GRECCAR6 was a phase III, multicenter, randomized, open-label, parallel-group controlled trial. Patients with cT3/T4 or Tx N+ tumors of the mid or lower rectum who had received RCT (45 to 50 Gy with fluorouracil or capecitabine) were included. Patients were randomly included in the 7-week or the 11-week (11w) group. Primary end point was the pCR rate defined as a ypT0N0 specimen.

Chief Investigator

Jeremie Lefevre
Prof.
Profile Link

Lead Centre

Hopital Saint-Antoine
184, rue du Faubourg Saint-Antoine
Paris
75012
France
Website

Collaboration and Funding

Collaborative Sites
Funding Sponsors

Additional Information

Full Research Summary
ESCP Affiliates